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多溴联苯(PBBs)对家畜和实验动物的毒性

Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

作者信息

Damstra T, Jurgelski W, Posner H S, Vouk V B, Bernheim N J, Guthrie J, Luster M, Falk H L

出版信息

Environ Health Perspect. 1982 Apr;44:175-88. doi: 10.1289/ehp.8244175.

DOI:10.1289/ehp.8244175
PMID:6282577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1568977/
Abstract

The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity, mutagenicity and carcinogenicity. The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs.

摘要

本文回顾了1973年密歇根州牛饲料意外污染事件中涉及的多溴联苯(Firemaster BP - 6或FF - 1)的成分、环境归宿及影响。本报告中提及的毒性作用仅限于在家养动物和实验动物中出现的情况,包括一般毒性、神经行为毒性、免疫毒性、生殖毒性、致突变性和致癌性。文中还讨论了这些多溴联苯的吸收、分布、生物转化和消除情况,以及它们与其他化学品和药物的相互作用。

相似文献

1
Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.多溴联苯(PBBs)对家畜和实验动物的毒性
Environ Health Perspect. 1982 Apr;44:175-88. doi: 10.1289/ehp.8244175.
2
Polybrominated biphenyls (PBB) environmental contamination in Michigan, 1973-1976.1973 - 1976年密歇根州多溴联苯(PBB)的环境污染
Environ Res. 1977 Feb;13(1):74-93. doi: 10.1016/0013-9351(77)90006-8.
3
Toxicity and residue studies in dairy animals with firemaster FF-1 (polybrominated biphenyls).用防火剂FF - 1(多溴联苯)对奶牛进行的毒性和残留研究。
Environ Health Perspect. 1978 Apr;23:91-7. doi: 10.1289/ehp.782391.
4
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action.多氯联苯(PCBs)和多溴联苯(PBBs):生物化学、毒理学及作用机制
Crit Rev Toxicol. 1984;13(4):319-95. doi: 10.3109/10408448409023762.
5
Investigation of hyperkeratotic activity of polybrominated biphenyls in Firemaster FF-1.对防火剂FF-1中多溴联苯的角化过度活性的研究。
J Toxicol Environ Health. 1982 May-Jun;9(5-6):877-87. doi: 10.1080/15287398209530210.
6
Assessment of the hazards of polybrominated biphenyls.多溴联苯危害评估。
Environ Health Perspect. 1978 Apr;23:351-65. doi: 10.1289/ehp.7823351.
7
Polybrominated biphenyls.多溴联苯
IARC Monogr Eval Carcinog Risk Chem Hum. 1978 Oct;18:104-24.
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Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs.多卤代联苯的致癌性:多氯联苯和多溴联苯。
Crit Rev Toxicol. 1990;20(6):440-96. doi: 10.3109/10408449009029331.
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Toxicity of polybrominated biphenyl and its effects on reproduction of White Leghorn hens.多溴联苯的毒性及其对白来航母鸡繁殖的影响。
Poult Sci. 1978 Jul;57(4):1027-36. doi: 10.3382/ps.0571027.
10
NTP Toxicology and Carcinogenesis Studies of Polybrominated Biphenyls (CAS No. 67774-32-7)(Firemaster FF-1(R)) in F344/N Rats and B6C3F1 Mice (Feed Studies).多溴联苯(化学物质登记号:67774-32-7)(商品名:Firemaster FF-1(R))在F344/N大鼠和B6C3F1小鼠中的NTP毒理学与致癌性研究(饲料喂养研究)
Natl Toxicol Program Tech Rep Ser. 1993 Aug;398:1-235.

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J Womens Health (Larchmt). 2011 Sep;20(9):1269-78. doi: 10.1089/jwh.2010.2275. Epub 2011 Jul 28.
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The role of structure in the disposition of halogenated aromatic xenobiotics.结构在卤代芳香族外源化合物处置中的作用。
Environ Health Perspect. 1985 Sep;61:11-20. doi: 10.1289/ehp.856111.

本文引用的文献

1
Michigan's PBB Incident: Chemical Mix-Up Leads to Disaster.密歇根州多溴联苯事件:化学品混淆引发灾难。
Science. 1976 Apr 16;192(4236):240-3. doi: 10.1126/science.192.4236.240.
2
Animal toxicology.动物毒理学
Environ Health Perspect. 1978 Jun;24:173-85. doi: 10.1289/ehp.7824173.
3
Human exposure to polychorinated biphenyls and polybrominated biphenyls.人类接触多氯联苯和多溴联苯的情况。
Environ Health Perspect. 1978 Jun;24:157-72. doi: 10.1289/ehp.7824157.
4
Metabolism and biochemical toxicity of PCBs and PBBs.多氯联苯和多溴联苯的代谢与生化毒性。
Environ Health Perspect. 1978 Jun;24:147-55. doi: 10.1289/ehp.7824147.
5
Induction of liver tumors in female Sherman strain rats by polybrominated biphenyls.多溴联苯对雌性谢尔曼品系大鼠肝脏肿瘤的诱导作用。
J Natl Cancer Inst. 1981 Mar;66(3):535-42.
6
Polybrominated biphenyl: acute and chronic effect on iron absorption and benzo(a)pyrene hydroxylase.多溴联苯:对铁吸收和苯并(a)芘羟化酶的急性和慢性影响。
Toxicol Appl Pharmacol. 1980 Jun 15;54(1):41-7. doi: 10.1016/0041-008x(80)90006-x.
7
The antibody-mediated and delayed type hypersensitivity response of mice exposed to polybrominated biphenyls.暴露于多溴联苯的小鼠的抗体介导和迟发型超敏反应。
Toxicol Appl Pharmacol. 1980 Mar 30;53(1):1-7. doi: 10.1016/0041-008x(80)90373-7.
8
Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster.由FireMaster的一种成分2,3',4,4',5-五溴联苯诱导细胞色素P-450和P-448。
Biochem Biophys Res Commun. 1980 Jan 15;92(1):175-82. doi: 10.1016/0006-291x(80)91536-3.
9
Inhibition of N-2-fluorenylacetamide-induced mammary tumorigenesis in rats by dietary polybrominated biphenyls.膳食多溴联苯对N-2-芴基乙酰胺诱导的大鼠乳腺肿瘤发生的抑制作用。
J Natl Cancer Inst. 1980 Jan;64(1):63-7.
10
Studies on the increased biliary flow produced by phenobarbital in rats.苯巴比妥对大鼠胆汁分泌增加的研究。
J Pharmacol Exp Ther. 1971 Mar;176(3):743-51.