González-Gómez A, García-Barreto D, Cabrera R, Toruncha A, Hernández-Cañero A
Pharmacology. 1982;25(1):33-8. doi: 10.1159/000137721.
The effects of oral treatment with atenolol and propranolol on blood pressure, heart rate and plasma cyclic adenosine 3':5'-monophosphate (cAMP) were studied in a group of young borderline hypertensives. Observations were accomplished after a period of recumbent relaxation and also following physiological stress testing. The latter significantly increased blood pressure, heart rate and plasma cAMP. A direct relationship was found between heart rate and plasma cAMP at rest and also following psychological stress. This relationship was lost following drug treatments. Both beta-blockers significantly reduced all measured variables in both conditions. However, plasma cAMP was most affected by propranolol.
在一组年轻的临界高血压患者中，研究了口服阿替洛尔和普萘洛尔对血压、心率及血浆环磷腺苷（cAMP）的影响。观察是在一段卧位休息期后以及生理应激测试后进行的。后者显著增加了血压、心率及血浆cAMP。在静息状态及心理应激后，发现心率与血浆cAMP之间存在直接关系。药物治疗后这种关系消失。两种β受体阻滞剂在两种情况下均显著降低了所有测量变量。然而，血浆cAMP受普萘洛尔的影响最大。
