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通过促肾上腺皮质激素释放因子的免疫中和作用抑制大鼠促肾上腺皮质激素的分泌。

Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor.

作者信息

Rivier C, Rivier J, Vale W

出版信息

Science. 1982 Oct 22;218(4570):377-9. doi: 10.1126/science.6289439.

DOI:10.1126/science.6289439
PMID:6289439
Abstract

Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.

摘要

给成年雄性大鼠静脉注射兔抗羊促肾上腺皮质激素释放因子（CRF）抗血清，可显著降低完整未应激大鼠中CRF诱导的血浆促肾上腺皮质激素（ACTH）升高，同时阻断在乙醚应激大鼠中观察到的超过75%的ACTH释放。此外，CRF抗血清可显著降低肾上腺切除动物的ACTH水平。这些结果表明内源性CRF在调节ACTH分泌中起生理作用。

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