Rönnbäck C, Nilsson A
Acta Radiol Oncol. 1982;21(2):121-8. doi: 10.3109/02841868209133994.
Female CBA mice were 90Sr-contaminated in utero by amounts ranging from 46 to 740 kBq given to the pregnant dams on the 19th day post coitum. The females were killed at an average age of 10 months. The ovaries were microscopically analysed and morphologic changes were recorded. Multiple corpora lutea were frequent in all but the two highest dose groups. Ovarian cysts were frequent as well. Proliferative events such as hyperplasia of luteinized interstitial cells and down-growths of the germinal epithelium did not occur until a dose of 185 kBq. The findings indicate a non-linear dose-tumor relationship, but also a direct proportion of animals with down-growths and those with tubular adenomas beyond a threshold of 14 per cent.
雌性CBA小鼠在子宫内受到90锶污染，在交配后第19天给怀孕母鼠注射的剂量范围为46至740千贝克勒尔。这些雌性小鼠在平均10个月龄时被处死。对卵巢进行显微镜分析并记录形态学变化。除了两个最高剂量组外，多个黄体很常见。卵巢囊肿也很常见。直到剂量达到185千贝克勒尔，才出现增殖性病变，如黄体化间质细胞增生和生发上皮向下生长。研究结果表明存在非线性剂量-肿瘤关系，但也表明，在超过14%的阈值后，生发上皮向下生长的动物与患有管状腺瘤的动物之间存在直接比例关系。
