利巴韦林对劳氏肉瘤病毒转化的影响。
Effect of ribavirin on Rous sarcoma virus transformation.
作者信息
Jenkins F J, Chen Y C
出版信息
Antimicrob Agents Chemother. 1981 Feb;19(2):364-8. doi: 10.1128/AAC.19.2.364.
Abstract
Ribavirin inhibited the expression of cellular transformation in normal rat kidney cells transformed by a temperature-sensitive mutant of rous sarcoma virus and chicken embryo fibroblasts infected with either a temperature-sensitive mutant or wild-type Rous sarcoma virus. Ribavirin also inhibited replication of the Rous sarcoma viruses in chicken embryo fibroblasts. The effect of ribavirin on cellular transformation was not permanent, as removal of the drug resulted in reversion to the transformed phenotype. The concentration of ribavirin necessary to inhibit the expression of cellular transformation was cytostatic for the cell lines used in this study.
摘要
利巴韦林抑制了由劳氏肉瘤病毒温度敏感突变体转化的正常大鼠肾细胞以及感染了温度敏感突变体或野生型劳氏肉瘤病毒的鸡胚成纤维细胞中的细胞转化表达。利巴韦林还抑制了劳氏肉瘤病毒在鸡胚成纤维细胞中的复制。利巴韦林对细胞转化的作用不是永久性的，因为去除药物后会导致恢复到转化表型。抑制细胞转化表达所需的利巴韦林浓度对本研究中使用的细胞系具有细胞生长抑制作用。
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