两种2-硝基萘并呋喃衍生物对劳氏肉瘤病毒感染的鸡胚成纤维细胞生长和转化诱导的选择性抑制作用
Selective inhibitory effect of two 2-nitronaphthofuran derivatives on growth and induction of transformation of Rous sarcoma virus-infected chicken embryo fibroblasts.
作者信息
Goldé A, Rouillard D, Buisson J P, Royer R
出版信息
Antimicrob Agents Chemother. 1983 Feb;23(2):328-31. doi: 10.1128/AAC.23.2.328.
Abstract
Two 2-nitronaphthofuran derivatives exhibited a dose-dependent lethal effect on Rous sarcoma virus-tranformed chicken embryo fibroblasts. When they were added at time of infection, they prevented cell transformation, but not virus replication, in a dose-dependent manner. Since the two derivatives inhibited mainly the DNA sythesis, we assume that they altered some early DNA-dependent cell event required for cell transformation and not for the integration of provirus.
摘要
两种2-硝基萘并呋喃衍生物对劳氏肉瘤病毒转化的鸡胚成纤维细胞表现出剂量依赖性致死效应。当在感染时添加它们时，它们以剂量依赖性方式阻止细胞转化，但不阻止病毒复制。由于这两种衍生物主要抑制DNA合成，我们推测它们改变了细胞转化所需的一些早期依赖DNA的细胞事件，而不是原病毒整合所需的事件。
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Selective inhibitory effect of two 2-nitronaphthofuran derivatives on growth and induction of transformation of Rous sarcoma virus-infected chicken embryo fibroblasts.两种2-硝基萘并呋喃衍生物对劳氏肉瘤病毒感染的鸡胚成纤维细胞生长和转化诱导的选择性抑制作用
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本文引用的文献
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Mutagenic activity of benzofurans and naphthofurans in the Salmonella/microsome assay: 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000), a new highly potent mutagenic agent.苯并呋喃和萘并呋喃在沙门氏菌/微粒体试验中的致突变活性：2-硝基-7-甲氧基-萘并[2,1-b]呋喃（R7000），一种新型高效致突变剂。
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Linkage of the endogenous avian leukosis virus genome of virus-producing chicken cells to inhibitory cellular DNA sequences.产病毒鸡细胞的内源性禽白血病病毒基因组与抑制性细胞DNA序列的连锁。
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