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[两性霉素B单侧引入脂质双分子层所诱导的离子通道]

[Ion channels, induced by amphotericin B introduced unilaterally into lipid bilayers].

作者信息

Brutian R A

出版信息

Biofizika. 1982 Jul-Aug;27(4):646-9.

PMID:6289919
Abstract

Single ionic channels of approximately 10 pS in magnitude and approximately 100 ms duration (in 2 M KCl solution) were recorded when amphotericin B (AB) was added to one side of a lipid bilayer. Using blocking ions it has been shown that these channels are asymmetrical half-pores (similar to those postulated by Marty and Finkelstein) which are capable of forming long-living symmetrical pores if AB is added to both sides of the membrane.

摘要

当在脂质双分子层的一侧添加两性霉素B(AB)时,记录到了大小约为10皮西门子、持续时间约为100毫秒(在2M氯化钾溶液中)的单离子通道。使用阻断离子已表明,这些通道是不对称半孔(类似于Marty和Finkelstein所假设的那些),如果在膜的两侧都添加AB,它们能够形成寿命较长的对称孔。

相似文献

1
[Ion channels, induced by amphotericin B introduced unilaterally into lipid bilayers].[两性霉素B单侧引入脂质双分子层所诱导的离子通道]
Biofizika. 1982 Jul-Aug;27(4):646-9.
2
[Effect of amphotericin B added to one side of a membrane].[两性霉素B添加至膜一侧的作用]
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The formation of amphotericin B ion channels in lipid bilayers.两性霉素B在脂质双分子层中形成离子通道。
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[Effect of monoclonal antibodies on the ionic permeability of a channel formed by amphotericin B in a lipid bilayer].[单克隆抗体对两性霉素B在脂质双分子层中形成的通道离子通透性的影响]
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8
[The electric potential at the entrance of the amphotericin channel].
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Large-conductance cholesterol-amphotericin B channels in reconstituted lipid bilayers.重构脂质双分子层中的大电导胆固醇-两性霉素B通道。
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[Permeability of bilayer lipid membranes to amphotericin B].
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