Bernardi G, Cherubini E, Marciani M G, Mercuri N, Stanzione P
Brain Res. 1982 Aug 12;245(2):267-74. doi: 10.1016/0006-8993(82)90809-5.
Considering that a well-defined dopaminergic projection from the mesencephalic structures to the rat frontal cortex has been demonstrated, the purpose of this research was to study the action of iontophoretically applied dopamine (DA) on intracellularly recorded rat frontal neurons. The stimulation of the substantia nigra (SN) and the ventral tegmental area (VTA) evoked EPSP-IPSP sequences in these cells. About 50% of the tested neurons, widely distributed in all the frontal cortex, responded to DA application and no difference in the response to DA was observed between neurons with monosynaptic inputs and neurons with polysynaptic inputs. The catecholamine depolarized the cell membrane and decreased the firing rate, generally without significant changes in membrane resistance, as already observed in rat and cat striatal cells. In some neurons the decrease of the spikes preceded the membrane depolarization. Considering the complex effect of DA on the electrical properties of these neurons, these results seem to be indicative of a mechanism of action dependent on metabolic changes.
鉴于已经证实存在从中脑结构到大鼠额叶皮质的明确多巴胺能投射，本研究的目的是研究离子导入多巴胺（DA）对细胞内记录的大鼠额叶神经元的作用。刺激黑质（SN）和腹侧被盖区（VTA）可在这些细胞中诱发兴奋性突触后电位-抑制性突触后电位序列。大约50%的受试神经元广泛分布于整个额叶皮质，对DA的应用有反应，单突触输入神经元和多突触输入神经元对DA的反应未观察到差异。正如在大鼠和猫纹状体细胞中已经观察到的那样，儿茶酚胺使细胞膜去极化并降低放电频率，通常膜电阻无明显变化。在一些神经元中，放电频率的降低先于膜去极化。考虑到DA对这些神经元电特性的复杂作用，这些结果似乎表明存在一种依赖于代谢变化的作用机制。
