Yotsumoto H
Chest. 1982 Nov;82(5):556-9. doi: 10.1378/chest.82.5.556.
Serial measurements of serum angiotensin-converting enzyme activity were made to estimate its usefulness in following the course of 17 patients with sarcoidosis. In nine cases with spontaneous remissions, the enzyme levels decreased gradually, accompanied by improvements in chest radiologic findings. In eight patients given corticosteroids, the enzyme levels decreased rapidly preceding improvements in the chest roentgenograms. The levels returned to pretreatment values when there was radiologic relapse of disease. Reelevation of the enzyme level was also observed without determination of the chest radiologic findings in four of five patients who responded to therapy, but the elevated enzyme level remained lower than the pretreatment level. These observations suggest that the serum angiotensin-converting enzyme level reflects the activity of disease in untreated and corticosteroid-treated patients with sarcoidosis. However, a partial reelevation of the decreased enzyme activity in corticosteroid-treated patients does not necessarily indicate a relapse of the disease.
对17例结节病患者进行了血清血管紧张素转换酶活性的系列测定，以评估其在跟踪疾病进程中的作用。在9例自发缓解的病例中，酶水平逐渐下降，同时胸部放射学检查结果有所改善。在8例接受皮质类固醇治疗的患者中，酶水平在胸部X线片改善之前迅速下降。当疾病出现放射学复发时，酶水平恢复到治疗前值。在5例对治疗有反应的患者中，有4例在未进行胸部放射学检查时也观察到酶水平再次升高，但升高后的酶水平仍低于治疗前水平。这些观察结果表明，血清血管紧张素转换酶水平反映了未治疗和接受皮质类固醇治疗的结节病患者的疾病活动情况。然而，皮质类固醇治疗患者中酶活性下降后的部分再次升高并不一定表明疾病复发。
