Stĕpán J, Smetana K, Smolíková M, Likovský Z, Havelka S
Z Rheumatol. 1978 Jan-Feb;37(1-2):40-4.
Since the activation of nucleoli in lymphocytes reflected by the presence of nucleoli with more or less distinct nucleolonemata (compact nucleoli in the light microscope) in these cells is considered as a marker of the autoimmune disease development, nucleoli of lymphocytes were investigated in the peripheral blood (22 investigations) and knee joint fluid (52 investigations) of juvenile and adult persons with rheumatoid arthritis. The results clearly indicate that the investigated joint exudates possessed a higher number of "active" lymphocytes (lymphocytes with compact nucleoli) in comparison with the peripheral blood. This observation can be interpreted as an accumulation of stimulated immunocompetent cells in the target organ.
由于淋巴细胞中核仁的激活表现为这些细胞中存在或多或少具有明显核仁丝的核仁（光学显微镜下的致密核仁），这被视为自身免疫性疾病发展的一个标志，因此对患有类风湿性关节炎的青少年和成年人的外周血（22次研究）和膝关节液（52次研究）中的淋巴细胞核仁进行了研究。结果清楚地表明，与外周血相比，所研究的关节渗出液中“活跃”淋巴细胞（具有致密核仁的淋巴细胞）的数量更多。这一观察结果可解释为靶器官中受刺激的免疫活性细胞的积累。
