Römer D, Büscher H H, Hill R C, Maurer R, Petcher T J, Zeugner H, Benson W, Finner E, Milkowski W, Thies P W
Life Sci. 1982;31(12-13):1217-20. doi: 10.1016/0024-3205(82)90346-0.
Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no dependence potential.
