阿片类苯二氮䓬类药物替氟度及其光学异构体对小鼠自发运动活性的影响。
Effects of the opioid benzodiazepine tifluadom and its optical isomers on spontaneous locomotor activity of mice.
作者信息
Ruhland M, Zeugner H
出版信息
Life Sci. 1983;33 Suppl 1:631-4. doi: 10.1016/0024-3205(83)90582-9.
The opioid benzodiazepine tifluadom and its (+) and (-) enantiomers affect locomotor activity of mice with patterns different from those of diazepam or the prototype opioids morphine (mu) or bremazocine (kappa). Lacking the initial locomotor inhibition, the sum of activity of the two enantiomers does not comply with the effects of the racemic mixture, thus indicating a non-additive interaction. In addition to the opioid effects of tifluadom, the effective antagonisms to the locomotor stimulatory phase of this compound and its enantiomers by Ro 15-1788 points to some interaction with the benzodiazepine/GABA-receptor complex.
阿片类苯二氮䓬类药物替氟朵及其（+）和（-）对映体对小鼠运动活性的影响模式不同于地西泮或原型阿片类药物吗啡（μ）或布马佐辛（κ）。由于缺乏最初的运动抑制作用，两种对映体的活性总和不符合外消旋混合物的效应，因此表明存在非加性相互作用。除了替氟朵的阿片样作用外，Ro 15-1788对该化合物及其对映体运动刺激阶段的有效拮抗作用表明其与苯二氮䓬/GABA受体复合物存在某种相互作用。
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