MacDonald P C, Edman C D, Hemsell D L, Porter J C, Siiteri P K
Am J Obstet Gynecol. 1978 Feb 15;130(4):448-55. doi: 10.1016/0002-9378(78)90287-9.
The purpose of this study was to ascertain if a relationship exists between the transfer constant of conversion of plasma androstenedione to estrone ([rho]AE1BU) and total body weight or excessive body weight in 50 postmenopausal women, of whom 25 had adenocarcinoma of the endometrium and 25 had no endometrial disease. The [rho]AE1BU ranged from 0.015 to 0.129 in these 50 women. The [rho]AE1BU in the women with endometrial cancer was 0.051 +/- 0.006 (mean +/- S.E.), whereas that in the women with no endometrial disease was 0.039 +/- 0.004. These values are not significantly different (p greater than 0.05). The body weights of these 50 women ranged from 104 to 430 pounds. The weight of the patients with endometrial cancer was 234 +/- 16 pounds (mean +/- S.E.), and that for the women with no endometrial disease was 194 +/- 12 pounds. A statistically significant correlation (p less than 0.001) was found between [rho]AE1BU and body weight and between [rho]AE1BU and excessive body weight in both groups of women. Moreover, obesity and aging appear to act in concert to potentiate the conversion of plasma androstenedione to estrone in extraglandular sites since the [rho]AE1BU is considerably greater among obese postmenopausal women than among comparably obese premenopausal women.
本研究的目的是确定50名绝经后女性的血浆雄烯二酮转化为雌酮的转移常数（[rho]AE1BU）与总体重或超重之间是否存在关联，其中25名患有子宫内膜腺癌，25名无子宫内膜疾病。这50名女性的[rho]AE1BU范围为0.015至0.129。患有子宫内膜癌的女性的[rho]AE1BU为0.051±0.006（平均值±标准误），而无子宫内膜疾病的女性的[rho]AE1BU为0.039±0.004。这些值无显著差异（p大于0.05）。这50名女性的体重范围为104至430磅。患有子宫内膜癌的患者体重为234±16磅（平均值±标准误），无子宫内膜疾病的女性体重为194±12磅。在两组女性中，均发现[rho]AE1BU与体重以及[rho]AE1BU与超重之间存在统计学显著相关性（p小于0.001）。此外，肥胖和衰老似乎协同作用，增强了腺外部位血浆雄烯二酮向雌酮的转化，因为绝经后肥胖女性的[rho]AE1BU比绝经前同等肥胖女性的[rho]AE1BU要高得多。
