Edman C D, MacDonald P C
Am J Obstet Gynecol. 1978 Feb 15;130(4):456-61. doi: 10.1016/0002-9378(78)90288-0.
The purpose of this study was to evaluate the transfer constant of conversion of plasma androstenedione to estrone ([p]AE1BU) as a function of total body weight and excess body weight in ovulatory and anovulatory young adult women. Twenty-four ovulatory and 31 anovulatory women were studied; their weights ranged from 90 to 350 pounds. The [p]AE1BU among these women ranged from 0.006 to 0.048. The extent of conversion of plasma androstenedione to estrone was significantly correlated with total body weight and with excessive body weight in both ovulatory and anovulatory young women. However, the mean [p]AE1BU for the anovulatory women (0.018) was not significantly different from that of the ovulatory women (0.015). Indeed, when the [p]AE1BU values of ovulatory and anovulatory women of similar total body weight or excessive body weight were compared, no difference was found in the extent of conversion of plasma androstenedione to estrone between the two groups.
本研究的目的是评估排卵和不排卵的年轻成年女性中，血浆雄烯二酮转化为雌酮的转移常数（[p]AE1BU）与总体重和超重体重的关系。研究了24名排卵女性和31名不排卵女性；她们的体重范围为90至350磅。这些女性的[p]AE1BU范围为0.006至0.048。在排卵和不排卵的年轻女性中，血浆雄烯二酮向雌酮的转化程度与总体重和超重体重均显著相关。然而，不排卵女性的平均[p]AE1BU（0.018）与排卵女性的平均[p]AE1BU（0.015）无显著差异。实际上，当比较总体重或超重体重相似的排卵和不排卵女性的[p]AE1BU值时，两组之间血浆雄烯二酮向雌酮的转化程度没有差异。
