Nastac E, Chira M, Hozoc M, Athanasiu P, Teleguţă L, Suru M, Stoian M, Pirvu C
Virologie. 1982 Apr-Jun;33(2):123-32.
Mouse Ehrlich ascites carcinoma (EAC) cells proved to be a semipermissive substrate for in vivo cultivation of adenovirus 5 (Ad5) and SV40. The multiplication of SV40 in EAC cells was facilitated by the coinfection with Ad5. As demonstrated by ID and EID reactions, the virus progens isolated at the first passage after the mixed infection of EAC cells with Ad5 and SV40 possess an antigenic mosaic with fractions characteristic of the parental viruses and of the cell substrate in which they had cultivated in vitro and in vivo. The progens gave positive seroneutralization and complement fixation reactions only with antiserum to SV40.
小鼠艾氏腹水癌细胞被证明是腺病毒5型（Ad5）和猿猴空泡病毒40（SV40）体内培养的半允许性底物。Ad5与SV40共感染促进了SV40在EAC细胞中的增殖。如免疫扩散（ID）和蚀斑减少中和试验（EID）反应所示，EAC细胞与Ad5和SV40混合感染后第一代分离的病毒子代具有抗原嵌合体，其片段具有亲代病毒以及它们在体内和体外培养的细胞底物的特征。这些子代仅与抗SV40血清产生阳性血清中和反应和补体结合反应。
