Alvarez-Rodriguez Y, Alvarez-Noves J, Valladares Y, del Pozo M
Cytobios. 1982;34(135-36):191-206.
It is possible to obtain antisera to cancer-specific antigens of mouse Ehrlich ascites cancer (EAC) cells when chimera rabbits previously made unresponsive to immunological stimulation by normal mouse cells antigens are immunized with mouse cancer cells. Employing this specifically anti-cancerous immunoserum this work shows that EAC cells and TC-SV40 cells contain cross-reacting cancer-specific antigens. Exogenous DNA from EAC cells is demonstrated as being able to display its coded information when it is incorporated to endogenous TC-SV40 cell DNA whose activity has been previously inhibited by 5'-bromodeoxyuridine.
当先前对正常小鼠细胞抗原的免疫刺激无反应的嵌合兔用小鼠癌细胞免疫时，有可能获得针对小鼠艾氏腹水癌（EAC）细胞癌特异性抗原的抗血清。利用这种特异性抗癌免疫血清，这项工作表明EAC细胞和TC-SV40细胞含有交叉反应的癌特异性抗原。当EAC细胞的外源DNA掺入到其活性先前已被5'-溴脱氧尿苷抑制的内源性TC-SV40细胞DNA中时，证明其能够展示其编码信息。
