Chaudary M A, Millis R R, Davies G C, Hayward J L
Ann Surg. 1982 Dec;196(6):651-5. doi: 10.1097/00000658-198212001-00006.
An analysis of 270 patients undergoing microdochectomy for nipple discharge from a single identifiable duct, and without an associated lump, revealed that occult cancers were all accompanied by hemoglobin positive discharge. A simple method of detecting the presence of hemoglobin in the discharge is described. The incidence of cancer was found to be 5.9%. In order of frequency, intraduct papilloma, duct ectasia, cystic disease, and carcinoma accounted for over 90% of the cases. Six patients in whom no malignancy was seen in the microdochectomy specimen subsequently developed cancer in the ipsilateral breast. A close follow-up of all patients with hemoglobin positive discharge and in whom no cause for the discharge is demonstrated at microdochectomy is stressed.
对270例因单一可识别导管乳头溢液且无相关肿块而接受微导管切除术的患者进行分析后发现，隐匿性癌症均伴有血红蛋白阳性溢液。本文描述了一种检测溢液中血红蛋白存在的简单方法。发现癌症的发生率为5.9%。按发生频率排序，导管内乳头状瘤、导管扩张症、囊性疾病和癌占病例的90%以上。6例在微导管切除标本中未发现恶性病变的患者随后在同侧乳房发生了癌症。强调对所有血红蛋白阳性溢液且在微导管切除术中未发现溢液原因的患者进行密切随访。
