Modrich P
CRC Crit Rev Biochem. 1982;13(3):287-323. doi: 10.3109/10409238209114231.
Type II DNA restriction and modification systems are ideally suited for analysis of mechanisms by which proteins specifically recognize unique DNA sequences. Each system is comprised of a unique DNA recognition site and two enzymes, which in those cases examined in detail, are comprised of distinct polypeptide chains. Thus, not only are the DNA substrates extremely well defined, but each system affords the opportunity to compare distinct proteins which interact with a common DNA sequence. This review will focus only on those Type II systems which have been examined in sufficient molecular detail to permit some insight into modes of specific DNA-protein interaction.
II型DNA限制与修饰系统非常适合用于分析蛋白质特异性识别独特DNA序列的机制。每个系统都由一个独特的DNA识别位点和两种酶组成，在那些经过详细研究的案例中，这两种酶由不同的多肽链组成。因此，不仅DNA底物定义极为明确，而且每个系统都提供了比较与共同DNA序列相互作用的不同蛋白质的机会。本综述将仅聚焦于那些已经在分子层面进行了充分研究、足以让人深入了解特定DNA-蛋白质相互作用模式的II型系统。
