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人类睾丸发育以及中肾在双支持细胞系统起源中的作用。

Human testicular development and the role of the mesonephros in the origin of a dual Sertoli cell system.

作者信息

Wartenberg H

出版信息

Andrologia. 1978 Jan-Feb;10(1):1-21. doi: 10.1111/j.1439-0272.1978.tb01306.x.

DOI:10.1111/j.1439-0272.1978.tb01306.x
PMID:629409
Abstract

Some aspects of the development of the human testis (and overy) are discussed and the main theories regarding gonadal differentiation summarized. The major part of this review deals with the origin and differentiation of the three groups of somatic cellular content: Sertoli cells, Leydig cells and peritubular cells. The most important role of the mesonephros in gonadal development is described. Under the influence of the mesonephros, a second type of meiosis-inducing Sertoli cell differentiates and becomes the opponent of a meiosis-preventing type of Sertoli cell which derives from the coelomic epithelium. All somatic cells are pooled in the central gonadal blastema which is part of the medulla. They migrate via the rete blastema to the sites of their final differentiation. Included are the precursors of the Leydig cells and the peritubular cells.

摘要

本文讨论了人类睾丸(及卵巢)发育的某些方面,并总结了关于性腺分化的主要理论。本综述的主要部分涉及三组体细胞成分的起源和分化:支持细胞、间质细胞和睾丸周细胞。描述了中肾在性腺发育中的最重要作用。在中肾的影响下,第二种诱导减数分裂的支持细胞分化,并成为源自体腔上皮的防止减数分裂的支持细胞类型的对立面。所有体细胞都汇集在中央性腺胚基中,该胚基是髓质的一部分。它们通过网胚基迁移到最终分化的部位。其中包括间质细胞和睾丸周细胞的前体。

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