一种微小核糖核酸病毒中的串联重复基因。
A tandem repeat gene in a picornavirus.
作者信息
Forss S, Schaller H
出版信息
Nucleic Acids Res. 1982 Oct 25;10(20):6441-50. doi: 10.1093/nar/10.20.6441.
Abstract
Three closely related genes for the small genome-linked protein (VPg) of picornaviruses have been identified by sequence analysis as a tandem repeat in the genome of Foot and Mouth Disease Virus (FMDV), strain O1K. This unusual structure was also found in the genome of strain C1O, belonging to a different FMDV serotype. Predicted biochemical properties of the three VPg gene products are in excellent agreement with the data from protein analysis of a heterogeneous VPg population from a third FMDV serotype, strain A10 (1). Taken together, these data indicate that the VPgs from all three genes function equally well in vivo. This is the first report of a tandem repeat gene in a viral genome.
摘要
通过序列分析，已在口蹄疫病毒（FMDV）O1K株的基因组中鉴定出三个与小基因组连接蛋白（VPg）密切相关的基因，它们呈串联重复排列。在属于不同FMDV血清型的C1O株基因组中也发现了这种不同寻常的结构。三种VPg基因产物的预测生化特性与来自第三种FMDV血清型A10株的异质VPg群体的蛋白质分析数据高度吻合。综合这些数据表明，来自所有三个基因的VPg在体内功能同样良好。这是病毒基因组中串联重复基因的首次报道。
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本文引用的文献
1
Improvements of DNA sequencing gels.DNA测序凝胶的改进。
Anal Biochem. 1981 Aug;115(2):450-7. doi: 10.1016/0003-2697(81)90031-2.
2
Genome-linked proteins of viruses.病毒的基因组连接蛋白
Cell. 1982 Feb;28(2):199-201. doi: 10.1016/0092-8674(82)90335-x.
3
Recombination in RNA.RNA中的重组
Cell. 1982 Jul;29(3):921-8. doi: 10.1016/0092-8674(82)90454-8.
4
The nucleotide sequence of cDNA coding for the structural proteins of foot-and-mouth disease virus.编码口蹄疫病毒结构蛋白的cDNA的核苷酸序列。
Gene. 1982 Feb;17(2):153-61. doi: 10.1016/0378-1119(82)90068-3.
5
Computer programs for the analysis and the management of DNA sequences.用于DNA序列分析和管理的计算机程序。
Nucleic Acids Res. 1982 Jan 11;10(1):207-16. doi: 10.1093/nar/10.1.207.
6
A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide.通过用针对合成七肽的抗体进行免疫沉淀鉴定出的脊髓灰质炎病毒VPg的膜相关前体。
Cell. 1982 Feb;28(2):405-12. doi: 10.1016/0092-8674(82)90358-0.
7
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.脊髓灰质炎病毒cDNA的分子克隆及病毒基因组完整核苷酸序列的测定。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4887-91. doi: 10.1073/pnas.78.8.4887.
8
Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing.脊髓灰质炎病毒复制蛋白：编码P3-1b的RNA序列及蛋白水解加工位点。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3464-8. doi: 10.1073/pnas.78.6.3464.
9
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Virology. 1981 Jul 15;112(1):91-8. doi: 10.1016/0042-6822(81)90615-2.
10
Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus.口蹄疫病毒主要抗原基因的核苷酸序列及相应氨基酸序列。
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