Thornsberry C, Jones R N, Barry A L, Fuchs P C
Rev Infect Dis. 1982 Sep-Oct;4 Suppl:S316-24. doi: 10.1093/clinids/4.supplement_2.s316.
Cefotaxime is a new cephalosporin with a wide spectrum of antimicrobial activity. For broth and agar dilution tests, the MIC breakpoints suggested for defining bacterial susceptibility are less than or equal to 8 microgram/ml for susceptible, 16-32 microgram/ml for moderately susceptible (indeterminate), and greater than 32 microgram/ml for resistant. For disk diffusion tests, the zone diameter breakpoints suggested are greater than or equal to 23 mm for susceptible, 15-22 mm for moderately susceptible, and less than or equal to 14 mm for resistant. Examination of the bacteriologic outcome of infection for 1,440 patients treated with cefotaxime shows that the results of disk diffusion tests correlated well with clinical response. The organisms that had cefotaxime disk zones of greater than or equal to 23 mm were eradicated in 89% of cases. Clinical response of urinary tract infections due to Pseudomonas aeruginosa was unrelated to disk results for bacterial isolates; the rate of bacteriologic cure was 55%-64% regardless of category. It is further recommended that cefotaxime and other cephalosporins not be tested against the enterococci.
头孢噻肟是一种具有广泛抗菌活性的新型头孢菌素。对于肉汤稀释法和琼脂稀释法试验，用于定义细菌敏感性的最低抑菌浓度（MIC）断点为：敏感菌小于或等于8微克/毫升，中度敏感（不确定）菌为16 - 32微克/毫升，耐药菌大于32微克/毫升。对于纸片扩散法试验，建议的抑菌圈直径断点为：敏感菌大于或等于23毫米，中度敏感菌为15 - 22毫米，耐药菌小于或等于14毫米。对1440例接受头孢噻肟治疗的患者的感染细菌学转归进行检查显示，纸片扩散法试验结果与临床反应相关性良好。头孢噻肟纸片抑菌圈大于或等于23毫米的菌株在89%的病例中被清除。铜绿假单胞菌引起的尿路感染的临床反应与细菌分离株的纸片试验结果无关；无论类别如何，细菌学治愈率为55% - 64%。进一步建议不要针对肠球菌检测头孢噻肟和其他头孢菌素。
