Hoffman P C, Fraser D W, Hinson P L
Am Rev Respir Dis. 1978 Mar;117(3):527-31. doi: 10.1164/arrd.1978.117.3.527.
Delayed hypersensitivity reactions to skin test antigens prepared from rapidly growing mycobacteria were measured in patients with postoperative wound infections due to Mycobacterium chelonei and M. fortuitum. Sixteen of 19 patients with M. chelonei infection had more than 10 mm of induration to the M. chelonei purified protein derivative antigen (PPD-CG) and were significantly more likely to react to PPD-CG than patients or hospital personnel who had no evidence of infection. All but one patient had more induration with PPD-CG than with the antigen prepared from M. fortuitum (PPD-F). Three of 4 patients with M. fortuitum infection had greater than or equal to 9mm of induration with PPD-F and were significantly more likely than noninfected patients to react to PPD-F. Three of the 4 patients also had at least as much induration with PPD-F as with PPD-CG. In an outbreak of infections due to M. chelonei, testing with PPD-CG may be useful epidemiologically. Although the data are less clearly defined for PPD-F, testing with this antigen may be of value in an outbreak caused by M. fortuitum.
对从快速生长分枝杆菌制备的皮肤试验抗原的迟发型超敏反应，在因龟分枝杆菌和偶然分枝杆菌导致术后伤口感染的患者中进行了测量。19例龟分枝杆菌感染患者中有16例对龟分枝杆菌纯化蛋白衍生物抗原（PPD-CG）硬结超过10毫米，并且与没有感染证据的患者或医院工作人员相比，对PPD-CG产生反应的可能性显著更高。除1例患者外，所有患者对PPD-CG的硬结都比对从偶然分枝杆菌制备的抗原（PPD-F）的硬结更大。4例偶然分枝杆菌感染患者中有3例对PPD-F硬结大于或等于9毫米，并且与未感染患者相比，对PPD-F产生反应的可能性显著更高。这4例患者中有3例对PPD-F的硬结至少与对PPD-CG的硬结一样多。在一次由龟分枝杆菌引起的感染暴发中，用PPD-CG进行检测在流行病学上可能有用。虽然关于PPD-F的数据定义不太明确，但用该抗原进行检测在由偶然分枝杆菌引起的暴发中可能有价值。
