Armin A, Connelly E M, Rowden G
Am J Clin Pathol. 1983 Jan;79(1):37-44. doi: 10.1093/ajcp/79.1.37.
Five cases of granular cell myoblastoma have been studied for detection of the neuroectodermal protein S-100. Immunoperoxidase staining on paraffin sections, using an antibody raised against calf brain S-100 protein, was utilized to demonstrate positive cytoplasmic and nuclear reactivity in all cases. Negative staining in adjacent muscle and connective tissue elements was contrasted to in situ control staining of Schwann cells in peripheral nerves and staining of Langerhans cells and melanocytes in overlying stratified epithelia. These observations are interpreted as support for possible Schwann cell origin of granular cell myoblastomas.
对5例颗粒细胞瘤进行了研究，以检测神经外胚层蛋白S - 100。使用针对小牛脑S - 100蛋白产生的抗体，对石蜡切片进行免疫过氧化物酶染色，结果显示所有病例的细胞质和细胞核均呈阳性反应。相邻肌肉和结缔组织成分的阴性染色与周围神经中施万细胞的原位对照染色以及覆盖的复层上皮中朗格汉斯细胞和黑素细胞的染色形成对比。这些观察结果被解释为支持颗粒细胞瘤可能起源于施万细胞。
