Eaton A C, Bates C P
Br J Urol. 1982 Dec;54(6):653-7. doi: 10.1111/j.1464-410x.1982.tb13618.x.
A systematic in vitro physiological study of isolated human detrusor muscle strips is reported. Detrusor strips were obtained at operation. Pre-operative urodynamic studies enabled specimens to be classified as normal or unstable. Comparisons were made between responses of normal and unstable detrusor strips. The results provide evidence of a previously undescribed feedback-loop operating via pre-synaptic alpha-adrenoceptors which controls detrusor contractility. Further evidence is provided suggesting that an imbalance in this system is present in unstable detrusor muscle.
本文报道了一项对分离的人逼尿肌条进行的系统性体外生理学研究。逼尿肌条取自手术过程。术前尿动力学研究使标本能够被分类为正常或不稳定。对正常和不稳定逼尿肌条的反应进行了比较。结果提供了证据，表明存在一种以前未描述过的通过突触前α-肾上腺素能受体起作用的反馈回路，该回路控制逼尿肌收缩性。进一步的证据表明，不稳定逼尿肌中存在该系统的失衡。
