产气荚膜梭菌δ毒素对兔白细胞的选择性细胞毒性。
Selective cytotoxicity of Clostridium perfringens delta toxin on rabbit leukocytes.
作者信息
Jolivet-Reynaud C, Cavaillon J M, Alouf J E
出版信息
Infect Immun. 1982 Dec;38(3):860-4. doi: 10.1128/iai.38.3.860-864.1982.
Abstract
Clostridium perfringens delta toxin was selectively cytotoxic for various rabbit leukocyte populations. The sensitivity of these populations to the toxin varied, depending on the tissue from which they were derived, from 28% (appendix) to 41% (bone marrow) and 32% (spleen). Macrophages were uniformly killed by delta toxin, whereas thymocytes were essentially resistant. Selective cytotoxicity was correlated to the specific binding of the radiolabeled toxin by target cells. The relationship between sensitivity to the toxin and the presence of GM2 ganglioside in the cell membrane of rabbit leukocytes is discussed. Delta toxin might prove a useful new tool for separating leukocyte subpopulations based on their differential sensitivity to the cytolethal effect of this protein.
摘要
产气荚膜梭菌δ毒素对兔的各种白细胞群体具有选择性细胞毒性。这些细胞群体对毒素的敏感性各不相同，这取决于它们的来源组织，从28%（阑尾）到41%（骨髓）和32%（脾脏）。巨噬细胞会被δ毒素全部杀死，而胸腺细胞基本具有抗性。选择性细胞毒性与放射性标记毒素与靶细胞的特异性结合相关。本文讨论了兔白细胞细胞膜中对毒素的敏感性与GM2神经节苷脂的存在之间的关系。基于兔白细胞亚群对这种蛋白质细胞致死效应的不同敏感性，δ毒素可能会成为一种分离白细胞亚群的有用新工具。
相似文献
1
Selective cytotoxicity of Clostridium perfringens delta toxin on rabbit leukocytes.产气荚膜梭菌δ毒素对兔白细胞的选择性细胞毒性。
Infect Immun. 1982 Dec;38(3):860-4. doi: 10.1128/iai.38.3.860-864.1982.
2
Ganglioside identification on human monocyte membrane with Clostridium perfringens delta-toxin.用产气荚膜梭菌δ毒素鉴定人单核细胞膜上的神经节苷脂。
J Leukoc Biol. 1986 Jul;40(1):65-72. doi: 10.1002/jlb.40.1.65.
3
Interaction of Clostridium perfringens delta toxin with erythrocyte and liposome membranes and relation with the specific binding to the ganglioside GM2.产气荚膜梭菌δ毒素与红细胞及脂质体膜的相互作用及其与神经节苷脂GM2特异性结合的关系
Toxicon. 1989;27(10):1113-26. doi: 10.1016/0041-0101(89)90005-6.
4
In-vitro effects of Clostridium welchii type-D epsilon toxin on guinea-pig, mouse, rabbit and sheep cells.韦氏梭菌D型ε毒素对豚鼠、小鼠、兔和绵羊细胞的体外作用。
J Med Microbiol. 1978 Aug;11(3):299-302. doi: 10.1099/00222615-11-3-299.
5
Targeting of GM2-bearing tumor cells with the cytolytic Clostridium perfringens delta toxin.用溶细胞性产气荚膜梭菌δ毒素靶向携带GM2的肿瘤细胞。
Anticancer Drugs. 1993 Feb;4(1):65-75. doi: 10.1097/00001813-199302000-00009.
6
Structural Insights into Clostridium perfringens Delta Toxin Pore Formation.产气荚膜梭菌δ毒素孔形成的结构见解
PLoS One. 2013 Jun 21;8(6):e66673. doi: 10.1371/journal.pone.0066673. Print 2013.
7
Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2.产气荚膜梭菌δ毒素对血小板的损伤作用及其与神经节苷脂GM2的相关性
Arch Biochem Biophys. 1988 Apr;262(1):59-66. doi: 10.1016/0003-9861(88)90168-3.
8
Binding of Clostridium perfringens 125I-labeled delta-toxin to erythrocytes.产气荚膜梭菌125I标记的δ毒素与红细胞的结合
J Biol Chem. 1983 Feb 10;258(3):1871-7.
9
Beta2 toxin is not involved in in vitro cell cytotoxicity caused by human and porcine cpb2-harbouring Clostridium perfringens.β2 毒素与人和猪携带 cpb2 的产气荚膜梭菌在体外引起的细胞毒性无关。
Vet Microbiol. 2014 Jun 25;171(1-2):132-8. doi: 10.1016/j.vetmic.2014.03.020. Epub 2014 Mar 27.
10
Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues.产气荚膜梭菌α毒素（PLC）和产气荚膜梭菌溶素O（PFO）对巨噬细胞的细胞毒性、从巨噬细胞吞噬体逃逸以及产气荚膜梭菌在宿主组织中持续存在的影响。
Infect Immun. 2004 Sep;72(9):5204-15. doi: 10.1128/IAI.72.9.5204-5215.2004.
引用本文的文献
1
Delta-Toxin Damages the Mouse Small Intestine.德尔塔毒素损伤小鼠小肠。
Toxins (Basel). 2019 Apr 22;11(4):232. doi: 10.3390/toxins11040232.
2
Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis.产气荚膜梭菌δ毒素诱导细胞快速坏死。
PLoS One. 2016 Jan 25;11(1):e0147957. doi: 10.1371/journal.pone.0147957. eCollection 2016.
3
Structural Insights into Clostridium perfringens Delta Toxin Pore Formation.产气荚膜梭菌δ毒素孔形成的结构见解
PLoS One. 2013 Jun 21;8(6):e66673. doi: 10.1371/journal.pone.0066673. Print 2013.
4
NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens.产气荚膜梭菌坏死性肠炎分离株来源的穿孔毒素 NetB。
Toxins (Basel). 2010 Jul;2(7):1913-27. doi: 10.3390/toxins2071913. Epub 2010 Jul 23.
5
Crystallization and preliminary X-ray diffraction studies of delta-toxin from Clostridium perfringens.产气荚膜梭菌δ毒素的结晶及初步X射线衍射研究。
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):369-71. doi: 10.1107/S1744309110054187. Epub 2011 Feb 25.
6
Clostridium perfringens delta toxin is sequence related to beta toxin, NetB, and Staphylococcus pore-forming toxins, but shows functional differences.产气荚膜梭菌δ毒素与β毒素、NetB以及葡萄球菌成孔毒素在序列上相关，但表现出功能差异。
PLoS One. 2008;3(11):e3764. doi: 10.1371/journal.pone.0003764. Epub 2008 Nov 19.
7
Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B.人单核细胞对艰难梭菌毒素A和毒素B的细胞因子反应。
Infect Immun. 1991 Oct;59(10):3659-66. doi: 10.1128/iai.59.10.3659-3666.1991.
本文引用的文献
1
THE TYPES OF CLOSTRIDIUM PERFRINGENS.产气荚膜梭菌的类型。
J Pathol Bacteriol. 1964 Jul;88:279-83.
2
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
3
Studies on some soluble antigens of Clostridium welchii types B, C and D.对B型、C型和D型魏氏梭菌某些可溶性抗原的研究。
Immunology. 1958 Jul;1(3):268-90.
4
Gangliosides of calf thymus and of normal and leukemic bovine lymphocytes.
Eur J Biochem. 1980 Sep;110(2):475-83. doi: 10.1111/j.1432-1033.1980.tb04889.x.
5
Comparative study on ganglioside compositions of various rabbit tissues. Tissue-specificity in ganglioside molecular species of rabbit thymus.
Biochim Biophys Acta. 1981 Aug 24;665(2):214-20. doi: 10.1016/0005-2760(81)90005-9.
6
Ganglioside composition of rabbit thymus.兔胸腺的神经节苷脂组成
Biochim Biophys Acta. 1981 Aug 24;665(2):205-13. doi: 10.1016/0005-2760(81)90004-7.
7
Brain and thymus gangliosides: their molecular diversity and its biological implications and a dynamic annular model for their function in cell surface membranes.脑和胸腺神经节苷脂：它们的分子多样性及其生物学意义以及细胞表面膜中其功能的动态环形模型。
Mol Cell Biochem. 1980 Feb 8;29(2):81-90. doi: 10.1007/BF00220302.
8
Interactions between rabbit B and T lymphocytes in mitogenic response to staphylococcal protein A.兔B淋巴细胞与T淋巴细胞在对葡萄球菌蛋白A的有丝分裂原反应中的相互作用。
Cell Immunol. 1981 Jul 1;61(2):307-18. doi: 10.1016/0008-8749(81)90379-8.
9
Purification and characterization of Clostridium perfringens delta-toxin.产气荚膜梭菌δ毒素的纯化与特性分析
Infect Immun. 1981 Feb;31(2):536-46. doi: 10.1128/iai.31.2.536-546.1981.
10
Modulation of the immune response by antigen-reactive lymphocytes after cultivation with gangliosides.神经节苷脂培养后抗原反应性淋巴细胞对免疫反应的调节
J Immunol. 1975 Sep;115(3):839-43.
Zotero 插件