Buxton D
J Med Microbiol. 1978 Aug;11(3):299-302. doi: 10.1099/00222615-11-3-299.
Epsilon toxin, at relatively low concentrations, killed guinea-pig peritoneal macrophages in vitro. The cells became swollen, the nuclear and cytoplasmic membranes "blistered" and discontinuous, and the cytoplasm appeared structureless. Formalinised epsilon prototoxin was shown to bind closely to the outer surface of the cells and it is concluded that this site represents the location of the receptors for epsilon toxin. In addition the toxin at higher concentrations killed rabbit peritoneal macrophages after increased periods of incubation, but had no demonstrable effect on other cells from guinea-pigs, rabbits, mice and sheep.
在相对低的浓度下，ε毒素在体外可杀死豚鼠腹膜巨噬细胞。细胞肿胀，核膜和细胞质膜出现“水泡”且不连续，细胞质呈现无结构状态。已证明甲醛处理过的ε原毒素可紧密结合于细胞外表面，由此得出该位点代表ε毒素受体的位置。此外，较高浓度的该毒素在延长孵育时间后可杀死兔腹膜巨噬细胞，但对来自豚鼠、兔、小鼠和绵羊的其他细胞无明显作用。
