Arvin A M, Martin D P, Gard E A, Merigan T C
J Infect Dis. 1983 Jan;147(1):149-54. doi: 10.1093/infdis/147.1.149.
Erythrocebus patas monkeys were given placebo or human leukocyte interferon (5 x 10(5) units/kg of body weight per day im) for five days during an epizootic of simian varicella. During the 14 days beginning with the first day of treatment, the attack rate for simian varicella was 14.3% (two of 14) among interferon recipients compared to 70% (nine of 13) among placebo recipients (P less than 0.025). Excluding animals with antibody to simian varicella when the study began, 18% (two) of 11 interferon recipients had symptoms of infection compared to 80% (nine) of 11 placebo recipients (P less than 0.025). The epizootic began in a room housing male animals. The incidence of infection in male placebo recipients was 100% (seven of seven) compared to 14% (one of seven) in male interferon recipients (P less than 0.01). The efficacy of interferon prophylaxis in the simian varicella model supports its continued evaluation for the management of human varicella in high-risk patients.
在一次猴水痘流行期间，给红斑猴（Erythrocebus patas monkeys）连续五天注射安慰剂或人白细胞干扰素（每天每千克体重5×10⁵单位，肌肉注射）。从治疗第一天开始的14天内，接受干扰素治疗的猴子中猴水痘的发病率为14.3%（14只中有2只），而接受安慰剂治疗的猴子中发病率为70%（13只中有9只）（P<0.025）。排除研究开始时已具有抗猴水痘抗体的动物后，11只接受干扰素治疗的猴子中有18%（2只）出现感染症状，而11只接受安慰剂治疗的猴子中有80%（9只）出现感染症状（P<0.025）。疫情始于一间饲养雄性动物的房间。雄性接受安慰剂治疗的猴子感染率为100%（7只中有7只），而雄性接受干扰素治疗的猴子感染率为14%（7只中有1只）（P<0.01）。干扰素预防猴水痘模型的效果支持对其在高危患者中治疗人类水痘的持续评估。
