Felsenfeld A D, Abee C R, Gerone P J, Soike K F, Williams S R
Antimicrob Agents Chemother. 1978 Sep;14(3):331-5. doi: 10.1128/AAC.14.3.331.
Phosphonoacetic acid inhibited replication of simian varicella virus (Delta herpesvirus) in tissue culture. The drug was tested in patas monkeys 40 h after infection with Delta herpesvirus. A total of 200 mg/kg per day was given intramuscularly, divided into two doses every day for a total of 10 days. The treated monkeys were protected from clinical illness, and Delta herpesvirus was not recovered from their lymphocytes. Complement-fixing and neutralizing antibody titers were significantly lower in phosphonoacetic acid-treated monkeys than in the untreated controls. In animals given the drug alone, there was dermatitis and blackening of the skin and hair, serum glutamic oxalacetic transaminase and serum glutamic pyruvic transaminase enzymes were significantly increased, and liver biopsy revealed diffuse cytoplasmic swelling and granulation of the hepatocytes. The therapeutic range of this drug should be studied carefully before considering its use in severe varicella-zoster infection in humans.
膦甲酸钠可抑制猴水痘病毒（δ疱疹病毒）在组织培养中的复制。该药物在感染δ疱疹病毒40小时后的猕猴身上进行了测试。每天肌肉注射200毫克/千克，分两次给药，共给药10天。接受治疗的猕猴未出现临床疾病，其淋巴细胞中未分离出δ疱疹病毒。膦甲酸钠治疗的猕猴的补体结合抗体和中和抗体滴度明显低于未治疗的对照组。单独给予该药物的动物出现皮肤和毛发的皮炎和变黑，血清谷草转氨酶和血清谷丙转氨酶显著升高，肝活检显示肝细胞弥漫性细胞质肿胀和颗粒化。在考虑将该药物用于人类严重水痘-带状疱疹感染之前，应仔细研究其治疗范围。
