阿片类药物与经典条件作用：通过激活中枢神经系统内的阿片受体选择性消除条件反应。
Opiates and classical conditioning: selective abolition of conditioned responses by activation of opiate receptors within the central nervous system.
作者信息
Mauk M D, Madden J, Barchas J D, Thompson R F
出版信息
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7598-602. doi: 10.1073/pnas.79.23.7598.
Abstract
It has previously been shown that opiates produce selective abolition of aversively motivated classically conditioned responses in the rabbit. The experiments reported here show that these effects are mediated by specific activation of opiate receptors within the central nervous system in that this central activation is both necessary and sufficient to produce opiate-induced abolition of conditioned responding. Further characterization suggests that selective activation through opiate-mu-receptor interactions within the periaqueductal gray/periventricular region of the fourth ventricle may be critical in mediating this abolition.
摘要
先前的研究表明，阿片类药物能选择性消除家兔中由厌恶动机驱动的经典条件反射反应。此处报道的实验表明，这些效应是由中枢神经系统内阿片受体的特异性激活介导的，因为这种中枢激活对于产生阿片诱导的条件反应消除既是必要的也是充分的。进一步的特征分析表明，通过第四脑室导水管周围灰质/室周区域内阿片-μ受体相互作用的选择性激活，可能在介导这种消除中起关键作用。
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