Rudy J W, Cheatle M D
Dev Psychobiol. 1983 Jan;16(1):13-22. doi: 10.1002/dev.420160103.
The influence of LiCl preexposure on odor-aversion conditioning produced by an odor-LiCl pairing was studied in rats 7-31 days old. LiCl preexposure interfered with the acquisition of the odor aversion in both young and old pups. The time course of this effect depended, however, on the age of the pups. It lasted much longer (over 24 hr) if pups 8-17 days old were preexposed to LiCl than if the pups were preexposed when 30 days old (less 12 hr). Alternative interpretations of these data were discussed, and it was suggested that the age-dependent differences in the time course of the LiCl preexposed effect may be determined in part by age-related differences in the rat's excretory processes that clear lithium from the circulatory system.
研究了氯化锂预先暴露对7至31日龄大鼠由气味与氯化锂配对产生的气味厌恶条件反射的影响。氯化锂预先暴露干扰了幼崽和成年幼崽对气味厌恶的习得。然而，这种效应的时间进程取决于幼崽的年龄。如果8至17日龄的幼崽预先暴露于氯化锂，其持续时间会长得多（超过24小时），而如果幼崽在30日龄时预先暴露（少于12小时），则持续时间较短。讨论了这些数据的其他解释，并提出氯化锂预先暴露效应时间进程中与年龄相关的差异可能部分由大鼠清除循环系统中锂的排泄过程中与年龄相关的差异所决定。
