Kühn W, Heberling D, Höffken H, Rummel H H
Geburtshilfe Frauenheilkd. 1982 Dec;42(12):888-91. doi: 10.1055/s-2008-1037180.
Mixed muellerian tumours of the uterus are more common today than uterine leiomyosarcomata. There is a world wide increase in the incidence in the last few years. In the past 15 years we observed 20 mixed muellerian tumours of the uterine body. The patients are usually 10 years older than women with endometrial carcinoma or leiomyosarcoma of the uterus. Morphologically homologous and heterologous tumours must be differentiated. Characteristic is the marked polypoid growth. There is a close correlation between tumour stage and microscopic tumour grading. Tumours with high malignancy are usually in stage I or II. The prognosis correlates well with the grade and stage of the tumour, therefore the elaboration of a prognostic index is necessary. The survival rates are low. Mixed muellerian tumours are not at all or very little influenced by radiotherapy. The single or combined chemotherapies in use o date have not shown satisfactory success. As complete as possible surgical removal is therefore important. It cannot as yet be predicted whether our present combined treatment in stage III and stage IV by operation and post-operative combined chemotherapy with CYVADIC is liable to increase the survival rates.
子宫混合性苗勒管肿瘤如今比子宫平滑肌肉瘤更为常见。在过去几年中，其发病率在全球范围内呈上升趋势。在过去15年里，我们观察到20例子宫体混合性苗勒管肿瘤。这些患者通常比患有子宫内膜癌或子宫平滑肌肉瘤的女性大10岁。必须在形态学上区分同源性和异源性肿瘤。其特征是显著的息肉样生长。肿瘤分期与显微镜下肿瘤分级之间存在密切相关性。高恶性肿瘤通常处于I期或II期。预后与肿瘤的分级和分期密切相关，因此有必要制定一个预后指数。生存率较低。混合性苗勒管肿瘤对放疗完全没有或仅有很小的影响。目前使用的单一或联合化疗尚未取得令人满意的成效。因此，尽可能彻底的手术切除很重要。目前尚无法预测我们目前对III期和IV期患者采用手术及术后联合CYVADIC化疗的综合治疗是否会提高生存率。
