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小脑皮质中平行纤维与攀缘纤维联合刺激所诱导的平行纤维 - 浦肯野细胞传递的长时程抑制。

Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex.

作者信息

Ito M, Kano M

出版信息

Neurosci Lett. 1982 Dec 13;33(3):253-8. doi: 10.1016/0304-3940(82)90380-9.

DOI:10.1016/0304-3940(82)90380-9
PMID:6298664
Abstract

In rabbit cerebellar cortex, local stimulation of parallel fibers induced field potentials with two negative peaks, n1 representing conducting spikes of parallel fibers and n2 postsynaptic excitation in dendrites of Purkinje cells and other cortical cells. Conjunctive stimulation of parallel fibers and climbing fibers at 4 Hz for 30-120 sec caused a significant depression of n2 potential which lasted for at least 1 h. Such an effect could not be produced by stimulation of climbing fibers or parallel fibers alone. These observations support the plasticity assumption in the Marr-Albus model of the cerebellum.

摘要

在兔小脑皮质中，局部刺激平行纤维可诱发具有两个负峰的场电位，n1代表平行纤维的传导峰电位，n2代表浦肯野细胞和其他皮质细胞树突中的突触后兴奋。以4Hz频率联合刺激平行纤维和攀缘纤维30 - 120秒，可导致n2电位显著降低，且该效应至少持续1小时。单独刺激攀缘纤维或平行纤维不会产生这种效应。这些观察结果支持了小脑的马尔-阿尔布斯模型中的可塑性假设。

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Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex.小脑皮质中平行纤维与攀缘纤维联合刺激所诱导的平行纤维 - 浦肯野细胞传递的长时程抑制。
Neurosci Lett. 1982 Dec 13;33(3):253-8. doi: 10.1016/0304-3940(82)90380-9.
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