钙是小脑长时程抑制诱导中攀缘纤维的细胞内介质。
Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.
作者信息
Sakurai M
机构信息
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan.
出版信息
Proc Natl Acad Sci U S A. 1990 May;87(9):3383-5. doi: 10.1073/pnas.87.9.3383.
Abstract
In cerebellar Purkinje cells, conjunctive stimulation of parallel fibers and the climbing fiber causes long-term depression of parallel fiber-Purkinje cell transmission. It has been postulated that calcium is an intracellular mediator of the climbing fiber to induce this synaptic modification. To directly test the hypothesis, a calcium-chelating agent, EGTA, was intracellularly injected into Purkinje cells. In these injected cells, conjunctive stimulation failed to induce depression. Instead, it caused potentiation similar to that observed after repetitive stimulation of parallel fibers alone.
摘要
在小脑浦肯野细胞中，平行纤维与攀缘纤维的联合刺激会导致平行纤维-浦肯野细胞传递的长时程抑制。据推测，钙是攀缘纤维诱导这种突触修饰的细胞内介质。为了直接验证这一假说，将一种钙螯合剂乙二醇双四乙酸（EGTA）注入浦肯野细胞内。在这些注入了EGTA的细胞中，联合刺激未能诱导出抑制作用。相反，它引起了类似于单独对平行纤维进行重复刺激后所观察到的增强作用。
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