Racine R J, Milgram N W
Brain Res. 1983 Feb 7;260(2):201-16. doi: 10.1016/0006-8993(83)90675-3.
Several types of short-term postactivation potentiation (PAP) effect were examined in limbic forebrain pathways in the chronic rat. We tested 9 different stimulation sites and 1-3 target sites for each stimulation site. All pathways showed PAP effects following activation by single electrical pulses or pulse trains. Using exponential curve fitting procedures, we found that the decay curves could be best fitted by one, or a sum of 2-3, exponential curves. On the basis of time constants, these curves fell into 4 different categories: facilitation (tau = 80 ms), augmentation (tau = 7s), potentiation 1 (tau = 70s), and potentiation 2(tau = 6.5 min). The latter component was the one most reliably generated in the chronic preparation. Frequency facilitation (facilitation during a stimulation train) was also examined and it appeared to be based upon a mechanism similar to that underlying paired pulse facilitation. Evidence is presented that facilitation and augmentation may be based on the the same mechanism. The possibility that the remaining components involve different mechanisms is discussed.
在慢性大鼠的边缘前脑通路中，研究了几种类型的短期激活后增强（PAP）效应。我们测试了9个不同的刺激位点，每个刺激位点有1 - 3个靶点。所有通路在单次电脉冲或脉冲串激活后均表现出PAP效应。使用指数曲线拟合程序，我们发现衰减曲线可以用一条指数曲线，或2 - 3条指数曲线的总和来最佳拟合。根据时间常数，这些曲线分为4种不同类型：易化（时间常数τ = 80毫秒）、增强（τ = 7秒）、增强1（τ = 70秒）和增强2（τ = 6.5分钟）。后一种成分是在慢性制备中最可靠产生的。还研究了频率易化（刺激串期间的易化），它似乎基于与双脉冲易化相同的机制。有证据表明易化和增强可能基于相同的机制。讨论了其余成分涉及不同机制的可能性。
