Missale C, Govoni S, Castelletti L, Spano P F, Trabucchi M
Brain Res. 1983 Feb 28;262(1):160-2. doi: 10.1016/0006-8993(83)90481-x.
Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
与3个月大的年轻大鼠相比，发现25个月大的大鼠脊髓颈段和胸段中蛋氨酸脑啡肽免疫反应性物质含量降低。在腰段未检测到与年龄相关的变化。对胸段提取物进行的生物凝胶P 30柱色谱分析表明，在所研究的两个年龄组中，免疫反应性物质的组成相似。在胸段还测量了阿片受体结合情况。老年大鼠脊髓胸段的阿片受体数量增加。脊髓水平上这些与年龄相关的蛋氨酸脑啡肽免疫反应性含量和阿片受体数量变化可能有助于确定衰老过程中疼痛敏感性的改变。
