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衰老神经科学与神经生物学整合的神经科学基础

A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging.

机构信息

Department of Cellular, Development, and Integrative Biology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Evelyn F. McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):e19-e33. doi: 10.1093/gerona/glab301.

Abstract

Neuroscience has a rich history of studies focusing on neurobiology of aging. However, much of the aging studies in neuroscience occur outside of the gerosciences. The goal of this primer is 2-fold: first, to briefly highlight some of the history of aging neurobiology and second, to introduce to geroscientists the broad spectrum of methodological approaches neuroscientists use to study the neurobiology of aging. This primer is accompanied by a corresponding geroscience primer, as well as a perspective on the current challenges and triumphs of the current divide across these 2 fields. This series of manuscripts is intended to foster enhanced collaborations between neuroscientists and geroscientists with the intent of strengthening the field of cognitive aging through inclusion of parameters from both areas of expertise.

摘要

神经科学有着丰富的研究历史,专注于衰老的神经生物学。然而,神经科学中的许多衰老研究都是在老年科学之外进行的。本入门指南有两个目标:首先,简要强调一下衰老神经生物学的历史,其次,向老年科学家介绍神经科学家用于研究衰老的神经生物学的广泛方法。本入门指南附有相应的老年科学入门指南,以及对当前这两个领域之间鸿沟的挑战和成就的看法。这一系列论文旨在促进神经科学家和老年科学家之间的增强合作,通过纳入这两个专业领域的参数来加强认知衰老领域。

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