Worner T M
Drug Alcohol Depend. 1982 Oct-Nov;10(2-3):199-201. doi: 10.1016/0376-8716(82)90013-8.
The clinical history of an abstinent alcoholic developing paresthesias after one year's treatment with disulfiram (250 mg daily) is presented. Despite continued disulfiram in decreased dosage (125 mg daily), associated with multivitamin supplementation, marked improvement in symptoms and signs was noted, contrary to previous case reports. The peripheral sensorimotor neuropathy associated with disulfiram administration has been well described [1 - 8]. From those reports, it appears that symptoms may appear from several weeks to several months after the drug has been administered. Although the etiology of this neuropathy remains speculative, the usual treatment is to discontinue disulfiram once the toxicity develops. Presented here is the clinical course of a subject, whose neuropathic symptoms resolved with continued disulfiram administration at a lower daily dosage in conjunction with multivitamin therapy.
本文介绍了一名戒酒的酗酒者在接受双硫仑（每日250毫克）治疗一年后出现感觉异常的临床病史。尽管继续使用剂量减少的双硫仑（每日125毫克）并补充多种维生素，但症状和体征仍有显著改善，这与之前的病例报告相反。与双硫仑给药相关的周围感觉运动神经病变已有详细描述[1 - 8]。从这些报告来看，症状可能在用药后数周至数月出现。虽然这种神经病变的病因仍属推测，但通常的治疗方法是一旦出现毒性反应就停用双硫仑。本文介绍了一名患者的临床病程，其神经病变症状在继续每日服用较低剂量双硫仑并结合多种维生素治疗后得到缓解。
