Mitchell P, Moyle J
FEBS Lett. 1983 Jan 24;151(2):167-78. doi: 10.1016/0014-5793(83)80063-5.
A review of published experimental and interpretative knowledge concerning proton ejection associated with cytochrome c oxidation by artificial phospholipid vesicles inlaid with cytochrome c oxidase indicates that the detailed characteristics of the redox-linked proton ejection cannot be simply explained by proton pumping. We propose an alternative hypothesis according to which proton ejection is due to the redox-linked deprotonation of a complex involving phospholipid and cytochrome c at the surface of the vesicles. The postulates upon which this hypothesis depends are explicitly outlined, and some methods of testing the hypothesis are suggested.
一篇关于已发表的有关嵌入细胞色素c氧化酶的人工磷脂囊泡与细胞色素c氧化相关的质子喷射的实验和解释性知识的综述表明，氧化还原相关质子喷射的详细特征不能简单地用质子泵来解释。我们提出了另一种假设，根据该假设，质子喷射是由于囊泡表面涉及磷脂和细胞色素c的复合物的氧化还原相关去质子化。明确概述了该假设所依赖的假设，并提出了一些检验该假设的方法。
