Chang F N, Navickas I J, Au C, Budzilowicz C
Biochim Biophys Acta. 1978 Mar 29;518(1):89-94. doi: 10.1016/0005-2787(78)90118-1.
Methylated proteins from HeLa cell cytoplasmic ribosomes have been identified. At least seven proteins are methylated and four of them are mildly acidic. The nature of the methylated amino acid in each protein is presented. In synchronized HeLa cell culture, the extent of methylation for both subunits varies with the cell cycle. Methylation of the 40 S subunit occurs heavily in the late G1 phase whereas methylation of the 60 S subunit is most pronounced in the early S phase.
已鉴定出HeLa细胞质核糖体中的甲基化蛋白。至少有七种蛋白质被甲基化，其中四种为弱酸性。文中给出了每种蛋白质中甲基化氨基酸的性质。在同步化的HeLa细胞培养中，两个亚基的甲基化程度随细胞周期而变化。40S亚基的甲基化在G1期后期大量发生，而60S亚基的甲基化在S期早期最为明显。
