Scholl D R, Kahn S, Malavarca R, Astrin S, Skalka A M
J Virol. 1983 Feb;45(2):868-71. doi: 10.1128/JVI.45.2.868-871.1983.
A fragment of chicken DNA containing the left long terminal repeat of endogenous retrovirus ev-2 and flanking cellular sequences has been molecularly cloned and analyzed. Comparison with sequence data from the analogous regions of ev-1 and Rous-associated virus-0 viral DNA reveals similarities among flanking regions of the integrated proviruses and among all three long terminal repeats. From the latter finding, we conclude that the difference in level of expression of ev-2 and its progeny Rous-associated virus-0 provirus cannot be due to sequence differences in their upstream long terminal repeats.
一段包含内源性逆转录病毒ev-2左长末端重复序列及侧翼细胞序列的鸡DNA片段已被分子克隆并分析。与ev-1和劳氏相关病毒-0病毒DNA类似区域的序列数据比较显示,整合前病毒的侧翼区域之间以及所有三个长末端重复序列之间存在相似性。从后一个发现,我们得出结论,ev-2及其子代劳氏相关病毒-0前病毒表达水平的差异不可能归因于其上游长末端重复序列的序列差异。