Hoppen H O, Heuer R, Seidel G
Biomed Mass Spectrom. 1978 Feb;5(2):133-5. doi: 10.1002/bms.1200050207.
A sensitive and specific method for the determination of vincamine in plasma is described. The molecular ion (m/e 426) and the parent peak (m/e 367) of the TMS derivative are assayed simultaneously by selected ion monitoring. Sensitivity is 30 pg ml plasma. The suitability of the method for pharmacokinetic studies is assessed by measuring plasma level profiles in six volunteers receiving 20 mg of vincamine orally.
本文描述了一种测定血浆中长春胺的灵敏且特异的方法。通过选择离子监测同时测定TMS衍生物的分子离子（m/e 426）和母峰（m/e 367）。灵敏度为30 pg/ml血浆。通过测定6名口服20 mg长春胺的志愿者的血浆浓度曲线来评估该方法用于药代动力学研究的适用性。
