Finagin L K, Kozhura I M, Zaika M U
Biull Eksp Biol Med. 1978 Feb;85(2):155-7.
The quantity of bile secreted during 24 hours and the concentration of total bile acids in adult 11--12-months-old and aged 27--29-month-old rats were determined by cannulation of common bile duct. As revealed, the difference in bile acid production and in the concentrations of cholesterol fractions in the liver and plasma between the adult and aged rats on a standard diet was insignificant. But the excretion of bile acids was markedly elevated both in adult and aged rats on atherogenous diet. The level of total and ester cholesterol in the plasma was higher in aged rats than in adult animals.
通过胆总管插管法测定了11 - 12月龄成年大鼠和27 - 29月龄老龄大鼠24小时胆汁分泌量及总胆汁酸浓度。结果显示，标准饮食条件下成年大鼠和老龄大鼠之间胆汁酸生成以及肝脏和血浆中胆固醇组分浓度的差异不显著。但是，在致动脉粥样化饮食条件下，成年大鼠和老龄大鼠的胆汁酸排泄均显著升高。老龄大鼠血浆中总胆固醇和酯胆固醇水平高于成年动物。
