Menon P V, Kurup P A
Biomedicine. 1976;24(4):248-53.
The effect of the fibre rich polysaccharide from black gram was studied on the concentration of cholesterol in the tissues, bile salts in the liver and faecal excretion of sterols and bile salts in rats fed normal and high fat cholesterol diet as compared to glucose and sucrose. The binding of bile salts "in vitro" by the polysaccharide was also studied. The rats fed polysaccharide showed the lowest level of cholesterol in the serum, liver and aorta both in normal and high fat -- cholesterol diet groups. Excretion of faecal sterols and bile salts was maximum in the animals fed polysaccharide. The concentration of bile salts in the liver was also maximum in the animals of this group. There was significant binding of bile salts by the polysaccharide when either natural bile or pure bile salt solution was shaken with it. The extent of binding of bile salts was however decreased in the presence of fatty acids, which also released some of the absorbed bile salts from the polysaccharide on subsequent shaking.
研究了黑吉豆富含纤维的多糖对喂食正常和高脂肪胆固醇饮食的大鼠组织中胆固醇浓度、肝脏中胆汁盐以及粪便中固醇和胆汁盐排泄的影响，并与葡萄糖和蔗糖进行了比较。还研究了该多糖“体外”结合胆汁盐的情况。喂食多糖的大鼠在正常和高脂肪胆固醇饮食组中血清、肝脏和主动脉中的胆固醇水平最低。喂食多糖的动物粪便固醇和胆汁盐的排泄量最大。该组动物肝脏中胆汁盐的浓度也最高。当天然胆汁或纯胆汁盐溶液与多糖一起振荡时，多糖能显著结合胆汁盐。然而，在脂肪酸存在的情况下，胆汁盐的结合程度降低，随后振荡时脂肪酸还会从多糖中释放出一些吸收的胆汁盐。
