[兔大脑皮层神经胶质细胞和突触体对色氨酸的摄取]
[Tryptophan uptake by glia and synaptosomes of rabbit cerebral cortex].
作者信息
Bakhanashvili T A, Maĭsov N I, Aleksidze N G, Raevskiĭ K S
出版信息
Biull Eksp Biol Med. 1978 Feb;85(2):172-4.
The authors studied the engulfment of L-tryptophane-14C by gliacytes and synaptosomes of the rabbit cerebral cortex. The system of engulfment of the gliacytes was characterized by a high affinity to tryptophane (Km = 0.8 micrometer). Engulfment of tryptophane by synaptosomes had a lower affinity (Km = 50 micrometer). Psychotropic substances--chlorpromazine and imipramine produced an inhibitory influence on glial engulfment. The leading role of gliacytes in the trophic provision of the neurons and the normal course of neurodynamic processes is confirmed.
作者研究了兔大脑皮层神经胶质细胞和突触体对L-色氨酸-14C的摄取情况。神经胶质细胞的摄取系统对色氨酸具有高亲和力（米氏常数Km = 0.8微米）。突触体对色氨酸的摄取亲和力较低（Km = 50微米）。精神药物——氯丙嗪和丙咪嗪对神经胶质细胞的摄取产生抑制作用。这证实了神经胶质细胞在神经元营养供应和神经动力过程正常进程中的主导作用。
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