[Effect of enzymes involved in the contact phase of blood clotting on the functional activity of neutrophils related to phagocytosis].

The influence of the product of blood coagulation contact phase of factor XII and of its activated form on the reduction reaction of nitrobule terazolium by human neutrophils was investigated. In all the cases the product of blood coagulation contact phase induced substantial stimulation of neutrophils. The neutrophil reactions with factor XII were irregular. They were more regular and intensive after the activation of this factor. An assumption was made on the mediated influence of the product of blood coagulation contact phase on neutrophils through the activation of intercommunicated blood plasma enzyme systems.