Nakashima N, Goto K, Takeuchi J
Virchows Arch A Pathol Anat Histopathol. 1983;399(2):207-19. doi: 10.1007/BF00619580.
A case of malignant papillary cystadenoma lymphomatosum was investigated by light and electron microscopy. Histologically, the tumor consisted mainly of a characteristic papillary cystadenoma lymphomatosum, but the feature of epithelial components varied greatly in separate portions of the tissue; papillary adenoma-, tubular adenocarcinoma-, acinic cell tumor- or oncocytoma-like features were observed, the tumor cells showing "atypia" in major components. Numerous intracytoplasmic inclusions were found in many oncocytic cells arranged in acinar structure, and stained with PAS, AZAN or Alcian blue. Electron microscopically, large numbers of very large, swollen and closely packed mitochondria were observed in almost all the tumor cells. The intraplasmic inclusions were composed mainly of a long dense body enclosed by a single unit membrane, and the contents constituted bundles of fine filament running parallel to the longer axis. The inclusions were often observed to unite with lysosomes and to co-exist with secretory granules in the cytoplasm.
对一例恶性乳头状囊腺瘤性淋巴瘤进行了光镜和电镜研究。组织学上，肿瘤主要由特征性的乳头状囊腺瘤性淋巴瘤组成，但上皮成分的特征在组织的不同部位差异很大；观察到乳头状腺瘤样、管状腺癌样、腺泡细胞肿瘤样或嗜酸性细胞瘤样特征，肿瘤细胞在主要成分中表现出“异型性”。在许多呈腺泡结构排列的嗜酸性细胞中发现大量胞质内包涵体，并用PAS、AZAN或阿尔辛蓝染色。电镜下，几乎所有肿瘤细胞中均观察到大量非常大、肿胀且紧密排列的线粒体。胞质内包涵体主要由被单层单位膜包裹的长致密体组成，其内容物由平行于长轴排列的细丝束构成。常观察到包涵体与溶酶体结合，并与细胞质中的分泌颗粒共存。
