由血红素控制阻遏物诱导的兔网织红细胞裂解物中的异步珠蛋白链合成。
Asynchronous globin chain synthesis in rabbit reticulocyte lystates induced by hemin-controlled repressor.
作者信息
Franco R S, Hogg J W, Martelo O J
出版信息
Blood. 1978 Apr;51(4):653-8.
PMID:630115
Abstract
To define further the role of hemin-controlled repressor (HCR) in globin synthesis, we studied its effect on the synthesis of individual globin chains in a rabbit reticulocyte lysate cell-free system. In the presence of HCR there was a marked globin chain imbalance, resulting in a lowered alpha/beta ratio. These findings in vitro may have relevance to certain clinical heme deficiency states in which a similar globin chain imbalance has been observed.
摘要
为了进一步明确血红素控制的阻遏物（HCR）在珠蛋白合成中的作用，我们在兔网织红细胞裂解物无细胞体系中研究了其对单个珠蛋白链合成的影响。在有HCR存在的情况下，出现了明显的珠蛋白链失衡，导致α/β比值降低。这些体外研究结果可能与某些临床血红素缺乏状态有关，在这些状态中已观察到类似的珠蛋白链失衡。
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