禽（v-fps）和哺乳动物（v-fes）逆转录病毒的转化基因对应于一个共同的细胞位点。

Transforming genes of avian (v-fps) and mammalian (v-fes) retroviruses correspond to a common cellular locus.

作者信息

Groffen J, Heisterkamp N, Shibuya M, Hanafusa H, Stephenson J R

出版信息

Virology. 1983 Mar;125(2):480-6. doi: 10.1016/0042-6822(83)90219-2.

Abstract

The Gardner (GA) and Snyder-Theilen (ST) isolates of feline sarcoma virus (FeSV) represent genetic recombinants between feline leukemia virus (FeLV) and transformation-specific sequences (v-fes gene) of cat cellular origin. A related transforming gene (v-fps), common to the Fujinami, PRC II, and UR 1 strains of avian sarcoma virus has also been described. Translational products of each of these recombinant virus isolates are expressed in the form of polyproteins exhibiting protein kinase activities with specificity for tyrosine residues. In the present study, v-fes and v-fps homologous sequences of GA-FeSV, ST-FeSV, and Fujinami sarcoma virus (FSV) are defined and these independently derived transforming genes are shown to correspond to a common cellular genetic locus which has remained highly conserved throughout vertebrate evolution.

摘要

猫肉瘤病毒（FeSV）的加德纳（GA）株和斯奈德-泰伦（ST）株代表了猫白血病病毒（FeLV）与猫细胞来源的转化特异性序列（v-fes基因）之间的基因重组体。还描述了一种与禽类肉瘤病毒的藤浪、PRC II和UR 1株共有的相关转化基因（v-fps）。这些重组病毒分离株的每一个的翻译产物都以多蛋白的形式表达，这些多蛋白表现出对酪氨酸残基具有特异性的蛋白激酶活性。在本研究中，定义了GA-FeSV、ST-FeSV和藤浪肉瘤病毒（FSV）的v-fes和v-fps同源序列，并且这些独立衍生的转化基因被证明对应于一个在整个脊椎动物进化过程中一直高度保守的共同细胞遗传位点。