Németh-Csóka M, Sárközi A
Acta Biol Acad Sci Hung. 1982;33(4):407-17.
A coulometric model system is described which facilitates the quantitative study of the kinetics of transformation of amorphous calcium phosphate (ACP) into calcium-hydroxy-apatite (CHA) crystals. Proteoglycans of high molecular weight and over-sulphated polysaccharides (Arteparon, dextran sulphate) delayed CHA crystal formation. The results have enabled us to characterize the structure activity relationship of inhibitors of CHA formation, and to postulate a general structural requirement for molecules with inhibitory effect. As working mechanism, binding of calcium ions by sulphate groups of polyanions was supposed, which might reversibly impair "the critical nuclei formation", and/or further deposition of calcium ions in the CHA crystals. The clinical, therapeutical significance of the determination of the threshold concentration of different compounds is discussed.
描述了一种库仑模型系统，该系统有助于对无定形磷酸钙（ACP）向羟基磷灰石（CHA）晶体转化动力学进行定量研究。高分子量蛋白聚糖和过度硫酸化多糖（Arteparon、硫酸葡聚糖）延迟了CHA晶体的形成。这些结果使我们能够表征CHA形成抑制剂的构效关系，并推测具有抑制作用的分子的一般结构要求。作为作用机制，推测多阴离子的硫酸根基团与钙离子结合，这可能会可逆地损害“临界晶核形成”和/或钙离子在CHA晶体中的进一步沉积。讨论了测定不同化合物阈值浓度的临床治疗意义。
