Effect of two new polysaccharides on growth, agglomeration and zeta potential of calcium phosphate crystals.

PURPOSE

To study the effect of semisynthetic sulphated polysaccharides in the different calcium phosphate crystallization processes in vitro.

MATERIALS AND METHODS

Crystallization of hydroxyapatite (HAP) and brushite (DCPD) in the presence and absence of 2 new semisynthetic sulphated polysaccharides (G871, G872) were defined by a constant composition technique, particle size analysis and zeta potential measurement.

RESULTS

These polysaccharides demonstrated strong inhibitory effect on HAP and DCPD crystal growth and agglomeration. The increase of negative zeta potential values after addition of polysaccharides suggests the binding of these polysaccharides to HAP and DCPD crystals.

CONCLUSION

We conclude that both G871 and G872 could be of potential use for calcium phosphate urolithiasis prevention in addition to their use for calcium oxalate.