Boevé E R, Cao L C, Deng G, De Bruijn W C, Schröder F H
Department of Urology, Erasmus University, Rotterdam, The Netherlands.
J Urol. 1996 Jan;155(1):368-73.
To study the effect of semisynthetic sulphated polysaccharides in the different calcium phosphate crystallization processes in vitro.
Crystallization of hydroxyapatite (HAP) and brushite (DCPD) in the presence and absence of 2 new semisynthetic sulphated polysaccharides (G871, G872) were defined by a constant composition technique, particle size analysis and zeta potential measurement.
These polysaccharides demonstrated strong inhibitory effect on HAP and DCPD crystal growth and agglomeration. The increase of negative zeta potential values after addition of polysaccharides suggests the binding of these polysaccharides to HAP and DCPD crystals.
We conclude that both G871 and G872 could be of potential use for calcium phosphate urolithiasis prevention in addition to their use for calcium oxalate.
研究半合成硫酸化多糖在体外不同磷酸钙结晶过程中的作用。
通过恒定组成技术、粒度分析和ζ电位测量，确定在存在和不存在两种新型半合成硫酸化多糖（G871、G872）的情况下羟基磷灰石（HAP）和透钙磷石（DCPD）的结晶情况。
这些多糖对HAP和DCPD晶体的生长和团聚表现出强烈的抑制作用。添加多糖后负ζ电位值的增加表明这些多糖与HAP和DCPD晶体发生了结合。
我们得出结论，G871和G872除了可用于预防草酸钙结石外，还可能具有预防磷酸钙尿路结石的潜在用途。
